Magma (Windows 95+, not NT4)

Magma (like ameba and Plazma) provides a multisensory
environment (sounds and images) which users can interact
with using pointing devices, switches, overlay keyboards
or their voice/sounds. It works particularly well with commercial
gamepads/joysticks with up to 11 buttons!

It responds to input with a variety of stimuli both visual and
auditory. It is similar to ameba and Plazma, but is generally
much more calming and “quieter”. It also has 26 pre-defined
display configurations and you can save 26 of your own to
bring back – if you make a display that you like – save it.

Input methods – Up to 8 keyboard or mouse activating
switches, Touch Screen/Mouse/Trackerball/Games Joystick
or Gamepad, microphone, keyboard, and Intellikeys keyboard.
All can be used together!