Plazma (Windows 95+, not NT4)

Plazma provides a multisensory environment (sounds
and images) which users can interact with using pointing
devices, switches, overlay keyboards or their voice/sounds.

It works particularly well with commercial gamepads/joysticks
with up to 11 buttons! It responds to input with a variety of
stimuli both visual and auditory. It is similar to ameba, but has
a more straightforward response to input. It also has 26 pre-
defined display configurations and you can save 26 of your
own to bring back. If you make a display that you like – save it.